Phgdh cancer
WebDec 31, 2024 · PHGDH is overexpressed in 16% of all cancers and diverse cancer types, including breast, melanoma, lung, colon, and pancreatic cancers [ 4 ]. PHGDH overexpression often leads to higher cell proliferation and greater metastasis, correlates with poor prognosis, and may cause drug resistance [ 6, 7 ]. WebNov 14, 2016 · Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality.
Phgdh cancer
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WebJun 1, 2016 · PHGDH was identified as a predictor for unfavorable prognosis in breast cancer but not in lung cancer, suggesting potential tissue-specific roles for PHGDH. Web研究表明，phgdh在多种人类肿瘤中呈高表达，如黑色素瘤、胰腺癌、宫颈癌和三阴性乳腺癌等。抑制phgdh可降低丝氨酸合成，抑制肿瘤细胞增殖、迁移和侵袭。因此，phgdh抑制剂可以作为治疗癌症的有效策略。
WebIdentifying increased PHGDH expression as a resistance mechanism for a variety of cancer therapeutics offers the opportunity to combine PHGDH inhibition with small molecule …
WebMay 18, 2024 · Phosphoglycerate dehydrogenase (PHGDH) catalyzes the first step in the synthesis of the amino acid serine, important for protein synthesis, one-carbon metabolism, lipid production, redox homeostasis, and other key processes of normal and cancer metabolism. While PHGDH is often overexpressed in cancer cells, how it is regulated has … WebImportantly, we find that PHGDHhigh breast cancer cell lines are exquisitely sensitive to inhibition of the NAD+ salvage pathway. Further, we find that PHGDH protein levels and those of the rate-limiting… Show more NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway.
WebApr 28, 2024 · A model in which PHGDH activity modulates redox homeostasis may reconcile prior studies investigating PHGDH's role in supporting serine-dependent cell anabolism. A major unsolved question in the field is understanding whether cancer cells utilize extracellular serine differently from serine synthesized de novo.
WebJun 4, 2024 · Among the genes identified, PHGDH is in a genomic region of recurrent copy number gain in breast cancer and PHGDH protein levels are elevated in 70% of estrogen receptor-negative breast cancers. PHGDH catalyzes the first step in the serine biosynthesis pathway, and breast cancer cells with high PHGDH expression have increased serine … nbc 6 newscastersWebFeb 20, 2024 · PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer. Clinicopathological data of endometrial cancer were downloaded from the Cancer Genome Atlas database (TCGA). marmion hockey clubWebNov 1, 2024 · In recent years, the importance of PHGDH in cancer has been gradually recognized. Suppressing PHGDH activity causes a reduction in serine synthesis and subsequent strong decrease in breast cancer cell proliferation ( 5 ). Enhanced PHGDH activity by the loss of PKC-ζ in mice promotes intestinal tumorigenesis ( 6 ). marmion track and fieldWebJan 3, 2024 · Being the rate-limiting enzyme within the serine biosynthesis pathway, phosphoglycerate dehydrogenase (PHGDH) is abnormally overexpressed in numerous malignant tumor cells and is a promising target for cancer treatment. Here, we report a series of novel PHGDH inhibitors using a focused compound screening and structural … nbc 6 news richmond vaWebAug 23, 2024 · Phosphoglycerate dehydrogenase (PHGDH) is an essential enzyme catalyzing the synthesis of amino acid serine. PHGDH is important for maintaining the poorly differentiated, stem-like state of cancer stem-like cells (CSLCs). Typically, high levels of PHGDH associate with enhanced proliferation and poor prognosis in various types of … nbc 6 o\\u0027clock newsWebJan 4, 2024 · PHGDH is the first and rate-limiting enzyme in the de novo serine synthesis pathway (SSP). Two PHGDH subunits oligomerize to convert 3-phosphoglycerate to phosphohydroxypyruvate in an NAD + -dependent reaction. marmion the poemWebThe gene encoding the enzyme 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first committed step of serine biosynthesis, is overexpressed in tumors and cancer cell lines via focal amplification and nuclear factor erythroid-2-related factor 2 (NRF2)-mediated up-regulation. marmion st cottesloe