Memantine and whole brain radiation
Web9 okt. 2024 · Historically, whole brain radiation therapy (WBRT) has played a key role in the management of brain metastases, especially for patients with multiple lesions. … Web30 okt. 2012 · BOSTON – Memantine, a drug normally prescribed for slowing cognitive decline in Alzheimer’s disease, can help to preserve cognitive function in cancer patients who have undergone whole brain irradiation, a study showed. In a phase III trial, patients with brain metastases were randomly assigned to take 20 mg memantine (Namenda) …
Memantine and whole brain radiation
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Web9 apr. 2024 · Background: Memantine has shown clinical utility in preventing radiation-induced cognitive impairment, but the mechanisms underlying its protective effects … Web28 jan. 2024 · Treatment options for brain metastases include whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS), conventional surgery, and systemic therapies. WBRT is administered to the entire brain, typically over multiple treatments (although hippocampal-avoidance WBRT is more selective regarding the dose for …
WebRadiation-induced cognitive decline (RICD) is considered a late effect of radiation therapy (RT) occurring in 30% or more of patients alive at 4 months after partial or whole brain irradiation. For those living over 6 … Web10 feb. 2015 · Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain …
Web16 aug. 2013 · Memantine is a noncompetitive, low-affinity, open-channel blocker that has been shown to be neuroprotective in preclinical models. 8–10 In 2 placebo-controlled … WebCurrently, whole-brain radiotherapy (WBRT), forms of stereotactic radio- therapy including stereotactic radiosurgery (SRS) and ... 104 The first is a multicenter phase 3 trial measuring neurocognitive decline in patients with brain metastases receiving memantine and WBRT with or without hippocampal avoidance. 100 The primary end point is ...
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Web5 nov. 2024 · However, there are serious toxicities associated with whole brain radiotherapy including nausea, fatigue, alopecia, and irreversible cognitive decline (Chang et al., 2009). Due to the neuroprotective effects of memantine, its administration before and during whole brain radiotherapy resulted in a significant delay in the decline in cognitive ... technisub maskeWebDie Bestrahlung des Gehirns ist ein wichtiges Verfahren in der Behandlung maligner und benigner Erkrankungen mit zerebraler Beteiligung. Der mögliche akute oder chronische Einfluss auf kognitive Leistungen ist für die Alltagskompetenz und … eletu odibohttp://www.nrgoncology.org/Home/News/Post/comparing-hippocampal-avoidant-whole-brain-radiotherapy-to-stereotactic-radiosurgery-for-patients-with-10-or-fewer-brain-metastases-from-small-cell-lung-cancer-nrg-cc009 eleukon globalWeb15 dec. 2012 · Memantine, a drug used to treat Alzheimer’s disease, slowed cognitive decline in patients with brain cancer treated with whole-brain radiation therapy in a phase III trial reported at the 54th Annual Meeting of the American Society for Radiation Oncology (ASTRO), held recently in Boston. technisub maskaWeb16 jul. 2024 · Hippocampal-Avoidance Whole-Brain Radiotherapy (HA-WBRT) HA-WBRT in the single-arm phase II RTOG 0933 trial showed less NCD compared with a historical WBRT cohort.13 ... Pugh S, et al. Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG … elevacijaWeb20 sep. 2013 · Background To determine the protective effects of memantine on cognitive function in patients receiving whole-brain radiotherapy (WBRT).Methods Adult patients with brain metastases received WBRT ... eletronica ji parana roWeb9 mrt. 2024 · March 09 2024. NRG-CC009: Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or fewer Brain Metastases from Small Cell Lung Cancer. The NRG Oncology clinical trial NRG-CC009 is a phase III trial that will be comparing two procedures for patients with 10 … eleva4u4