Crm1 and p53
WebJul 3, 2013 · Chromosomal region maintenance 1 (CRM1) mediates p53 nuclear export. Although p53 SUMOylation promotes its nuclear export, the underlying mechanism is unclear. Here we show that tethering of a … WebSep 23, 2007 · To test this, we co-transfected GFP–Crm1 with Flag–WT p53 or Flag–p53EDE/A into p53 −/− MEFs. Similar levels of GFP–Crm1 and Flag–p53 were expressed in the transfectants . The ...
Crm1 and p53
Did you know?
WebJul 1, 2011 · In addition, p53 was found to repress Crm1 promoter activity, after induction with doxorubicin, with p53 siRNA blocking the effect. Crm1 promoter constructs with … WebFeb 1, 2024 · Blood Cancer Journal - XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis. ... (CRM1/XPO1), the key nuclear ...
WebJul 3, 2013 · The CRM1 C-terminal domain lacking the NES-binding groove interacts with tetrameric p53, and the proper folding of the p53 core domain, rather than the presence of the N or C-terminal tails,... WebOct 12, 2016 · CRM1 is the key exporter of multiple tumor-suppressor proteins , including Foxos, Rb1, p53, p21, p27, and survivin. Accumulating lines of evidence suggest that the misregulation of nuclear protein export dynamics is involved in cancer cell survival, tumor progression, and drug resistance [ 21 , 22 ].
WebNov 4, 2008 · Importantly, the elevated CRM1 protein level leads to an increased p53-CRM1 interaction in IMR32 cells, which can be blocked by apigenin and TAF1-RNAi (Fig. 3F). … WebDec 1, 2012 · These results further substantiated p53 involvement in CRM1 inhibition–mediated apoptosis and cell-cycle arrest exclusively in the wt p53 cells. Mdm2-mediated p53 ubiquitinylation exposes the latter's NES, promoting its interaction with CRM1 with a consequent enhancement of its nuclear export and cytoplasmic degradation …
WebNov 16, 2012 · Nutlin-3a disrupts MDM2-p53 interaction, increases cellular levels of p53 in both nucleus and cytoplasm, and activates p53 signaling in cells. p53 status is the major determinant of response to MDM2 inhibitors. p53 is shuttled between the nucleus and the cytoplasm, and CRM1 mediates its nuclear export. eufora business intelligenceWebApr 4, 2009 · Crm1 is known to export p53 from the nucleus into the cytoplasm of cervical cancer cells via the C-terminal NES of p53, 28 a function that is promoted by HPV E6. 21 Additionally, nuclear export is required for the efficient degradation of p53 in high-risk HPV-infected cells, 28 although nuclear degradation of p53 does occur at low levels. 21 ... eufora boosting powderWebThe nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage The nuclear exporter protein, Crm1, plays a key role in normal cell functioning, mediating the nucleo-cytoplasmic transport of cargo proteins. firing a managerWebFeb 25, 2024 · Upregulation of CRM1 would allow more growth regulatory proteins, such as c-myc or BCR-ABL, to be transported into the cytoplasm and activate downstream … firing a maroonWebSep 23, 2007 · To test this, we co-transfected GFP–Crm1 with Flag–WT p53 or Flag–p53EDE/A into p53 −/− MEFs. Similar levels of GFP–Crm1 and Flag–p53 were … firing a minorWebCRM1 inhibition rescued p53-dependent nuclear functions and sensitized NBAT1-depleted cells to genotoxic drugs. Combined inhibition of CRM1 … eufora formation whipped styling solutionWebHere, we identify the major poly (ADP-ribosyl)ated sites of p53 by PARP-1 and find that PARP-1-mediated poly (ADP-ribosyl)ation blocks the interaction between p53 and the … eufora boost