Chromopyrrolic
Webchromopyrrolic acid (CHEBI:41625) ChEBI > Main CHEBI:41625 - chromopyrrolic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models Formula C22H15N3O4 Net Charge 0 Average Mass 385.373 Monoisotopic Mass 385.10626 InChI WebApr 29, 2024 · What is claimed is: 1. A method of inhibiting or partially inhibiting activity of one or more PIM (proviral integration site for Moloney murine leukemia virus) kinase(s) comprising contacting a PIM kinase with a compound of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, solvate, hydrate, or N-oxide, prodrug, or isotopic …
Chromopyrrolic
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Webring rearrangement from indole-3-pyruvic acid and NH4+ by the action of chromopyrrolic acid synthase (VioB or StaD) (Asamizu et al. 2007; Hirano et al. 2008). C. violaceum genome analysis showed that the genes trpA–F and pabA–B encode the anthranilate synthase in the tryptophan pathway in the conversion of chorismate to anthranilate (see ... WebAug 19, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one …
Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebApr 5, 2012 · 4EIP, 4EIQ. PubMed Abstract: The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products …
WebJun 6, 2007 · Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Staurosporine isolated from Streptomyces sp. … WebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid. Journal Of The American Chemical Society, 128 (37). 12289-12298 doi:10.1021/ja063898m
WebJun 12, 2014 · With this methodology, several key intermediates of natural products have been effectively prepared, and the total syntheses of lycogarubin C and chromopyrrolic acid have been completed in high efficiency. Supporting Information Spectral data ( 1 H and 13 C) and data for the X-ray analysis.
WebJul 3, 2014 · An effective and concise approach to synthesis of tetrasubstituted pyrroles from readily available amino acid esters by the promotion of Cu (OAc)2 in conjunction with Mn (OAc)3 has been developed. This reaction proceeds through multiple dehydrogenations, deamination, and oxidative cyclization. now in the shopWebCatalytic Mechanism and Relevance to Cytochrome cPeroxidase. In theP450reactioncycle(SIFig.7A),theferricenzymefirstbinds the substrate and initiates a … now in the month of mayingWebMay 1, 2015 · We provide the first experimental evidence for intermediates being involved in catalysis by RebD in generating the chromopyrrolic acid (CPA) scaffold of … now in the newsWebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and … nicole henry mintzWebSep 25, 2007 · In the chromopyrrolic acid-soaked structure, residues 1 and 2 and 246–250 (of Chains A and B) and 418–421 (of Chain B) were not included in the model. In this … now in this banquet marty haugenWebMay 20, 2024 · 除以上概述的结构类型外，在深海链霉菌生物碱类化合物的生物合成基因簇中也发现了P450酶基因的踪迹.Ma等[78]在研究一株来自深海的链霉菌Streptomycessp.SCSIO 03032中产生的具有抗菌、抗肿瘤活性的吲哚咔唑类生物碱spiroindimicins的生物合成机制时发现，P450酶编码 ... nicole henry waiting in vainWebSep 1, 2006 · StaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the presence of RebC directs formation of arcyriaflavin A. (18)O-Labeling studies indicate that the oxygen(s) of the pyrrolinone and maleimide … nicole henshaw photography